Excessive-Power Pre-Exercise with 10g Tyrosine!

L-Tyrosine (HPLC) – 10,000 mg

Morphogen kicks off the AlphaGen formulation with a daring transfer – a whopping 10-gram dose of tyrosine.

Tyrosine is a staple pre-workout ingredient, and we write about it on a regular basis. However we nearly by no means see it dosed at greater than 2 or 3 grams per serving, and we actually haven’t ever seen 10 complete grams of it.

The dose deserves particular dialogue, so we’ll get into that, however first, some background:

L-tyrosine is a good pre-workout ingredient for 3 causes. The primary is that it may possibly assist your thyroid gland, the second is that it helps the physique produce neurotransmitters, and at last, throughout sleep deprivation, it may possibly assist restore cognitive efficiency to baseline.

1. Neurotransmitter (catecholamine) synthesis

   Tyrosine is a obligatory precursor for synthesizing dopamine, adrenaline, and noradrenaline — ^[1-3] three catecholamine neurotransmitters that play a vital position in focus, motivation, and power.

   

   It’s simple to see why we like tyrosine a lot – its derivatives convey the depth and focus! Picture courtesy Wikimedia

   These catecholamines are wanted to provoke and regulate varied points of the stress response, which is essential for peak efficiency within the gymnasium.

   Adrenaline and noradrenaline are additionally nice for physique composition, as each can lower urge for food and improve the physique’s fee of fats oxidation (burning).^[4]

2. Sleep deprivation

   Militaries world wide have studied tyrosine extensively for its anti-stress and wakefulness-promoting results. In response to one examine carried out by the United States navy, tyrosine is definitely higher than caffeine at growing alertness in sleep-deprived individuals.^[5,6]

3. Thyroid

   Your thyroid is arguably the grasp gland of the metabolism – correct thyroid operate is indispensable for athletic and cognitive efficiency, fats loss, and muscle constructing.

   It produces two hormones which can be energetic in tissues everywhere in the physique – triiodothyronine (T3) and thyroxine (T4). With a view to produce these hormones, the gland wants an enough provide of tyrosine.^[7,8]

   

   Lengthy story brief: No iodine or tyrosine, no thyroid hormone synthesis. Get sufficient iodine and tyrosine in!!

   Thyroid assist is a particular concern for the pre-workout goal market. Fitness center goers sometimes work out arduous, and so they periodically limit energy to enhance physique composition. Because it seems, each of those behaviors can considerably downregulate thyroid operate by elevating cortisol.^[9-11]

   The tougher you’re employed out and the extra you limit energy, the extra you improve the chance of growing thyroid issues.

   So, below these circumstances, a bit supplemental tyrosine may also help.

The dose – 10,000 mg!

We focus on the advantages of tyrosine supplementation fairly commonly, however once more, what’s particular right here is the dose.

Excessive-dose tyrosine (100 mg/kg) can vastly scale back environmental stress in people when uncovered to chilly.^[12]

There a number of research on high-dose tyrosine that we don’t normally get to quote, as a result of most complement manufacturers merely don’t use doses on this vary. So let’s check out what the high-dose tyrosine literature has to say about what you’ll be able to count on from Morphogen AlphaGen.

• Chilly and altitude tolerance

  In a single randomized, double-blind, placebo-controlled examine from 1989, 23 navy males between the ages of 18-20 have been uncovered to chilly and simulated altitude throughout 4.5 hour periods. The tyrosine group, who acquired a 100 mg/kg dose of tyrosine, confirmed large enhancements over the placebo group in each respect. They have been much less drained, had much less extreme complications, felt much less chilly, had much less muscular discomfort, and felt much less emotional misery.^[12]

  Additionally they did considerably higher on cognitive checks – reminiscence efficiency specifically. Actually, tyrosine reversed reminiscence deficits normally brought on by chilly publicity.^[12]

  Though the doses used on this examine diversified by physique weight, they have been, on common, much like the dose utilized in Morphogen AlphaGen – a 100 mg/kg dose works out to about 8,000 milligrams of tyrosine for 180 pound man.

• Blood stress discount throughout stress

  In one other randomized managed examine, this one from 1994, researchers used the identical tyrosine dose – 100 mg/kg – in a inhabitants of 16 wholesome younger female and male topics between the ages of 23 and 35.^[13]

  The examine volunteers have been uncovered to environmental stress within the type of a 90 decibel observe of business noise – a stimulus identified to extend diastolic blood stress (5-12%), imply arterial stress (3-7%) and complete peripheral resistance (11-13%) in wholesome younger topics.^[13]

  This type of stress can be identified to trigger disorientation and efficiency reductions on cognitive checks.^[13]

  The researchers discovered that topics who acquired tyrosine fared significantly better total than these within the placebo group – 5-10% higher on varied cognitive duties, and had a lot decrease blood stress.^[13]

  Common diastolic blood stress within the placebo group was about 76 mmHg; within the tyrosine group it was solely 72.^[13]

So what does it imply?

The fight-or-flight response is mediated by noradrenergic neurons,^[12,14] and high-dose tyrosine seems to modulate it. For instance, in each research we cited, the authors noticed a lower in stress-induced vasoconstriction.

This is usually a good or a nasty factor, relying in your objectives. For the common gym-goer, high-dose tyrosine may also help tolerate excessive doses of ergogenic stimulants, enabling higher athletic efficiency with out going overboard on negative effects. Caffeine, for instance, is a infamous peripheral vasoconstrictor, however we predict the tyrosine in Morphogen AlphaGen can considerably attenuate this impact.

Utilizing high-dose tyrosine remains to be uncharted waters for the complement business, so we’re very curious to listen to the buyer suggestions on this one. However since no critical adversarial results have been famous within the research we reviewed,^[12,13] we’re very optimistic about the way forward for this tyrosine use case!

L-Citrulline DL-Malate (2:1) (HPLC) – 8,000 mg

Citrulline malate is citrulline certain to malic acid. Each of those molecules have their very own advantages, however the headliner right here is citrulline – and citrulline malate yields about 56% pure citrulline by weight. So now we have roughly 4.5 grams of citrulline right here.

Advantages of citrulline

Citrulline is a good nitric oxide (NO) boosting ingredient,^[7] and is presently the business’s customary selection for this objective due to its low value, excessive efficacy, and glorious security profile.

As a conditionally important amino acid, citrulline is produced by the physique, however solely in restricted portions. Which means supplementation with additional exogenous citrulline can yield advantages you wouldn’t see from regular endogenous citrulline synthesis.

The Arginine Citrulline Cycle. Picture courtesy Wikimedia commons (pink edits are ours)

Citrulline is a vital participant in each the NO cycle and the urea cycle. It’s transformed into arginine after which into NO by the enzyme argininosuccinate.^[15]

One fascinating factor to notice about citrulline is that it truly isn’t probably the most direct precursor to NO – that will be arginine, into which citrulline will get transformed by the enzyme argininosuccinate.

Arginine is then transformed into NO.

Earlier than citrulline, arginine was the business’s customary NO booster. However, because it seems, the oral bioavailability of arginine is fairly unhealthy, making citrulline supplementation a more practical technique for enhancing NO.^[16,17]

NO upregulation improves athletic efficiency

As most readers in all probability already know, upregulating NO, i.e. via citrulline supplementation, can set off a mechanism known as vasodilation, through which your arteries broaden in diameter. Greater arteries implies that blood flows extra simply all through the physique, an impact known as decreased cardiovascular resistance.

Consequently, your coronary heart doesn’t need to work as arduous, resulting in drops in blood stress and coronary heart fee.^[18-20] This course of has apparent advantages for most individuals, however there’s one more reason NO boosters present up in pre-workouts, and that’s elevated athletic efficiency.

Improved circulation implies that the physique can ship oxygen and vitamins to muscle cells extra effectively, and take away mobile waste extra effectively. Cardio effectivity will also be improved.

Citrulline’s participation within the nitric oxide cycle and the urea cycle. The enzyme argininosuccinate converts citrulline to arginine, and arginine stimulates the manufacturing of nitric oxide^[15]

It may well additionally result in muscle swelling as blood and water are permitted to enter muscle tissue extra simply – an impact most bodybuilders are accustomed to. It’s generally known as the pump.

These two issues – decreased cardiovascular resistance, and improved metabolic effectivity – are the fundamental mechanisms underlying the next advantages of citrulline supplementation:

• Elevated oxygen utilization and energy output^[21]
• Elevated athletic endurance^[22]
• Diminished muscle soreness after train^[22]
• Progress hormone upregulation in response to train^[23]
• Diminished muscle catabolism^[24]
• Elevated muscle protein synthesis^[25,26]

Citrulline, ornithine and ammonia

There’s another reason why citrulline is a superb selection of NO-boosting ingredient: itsimpact in your physique’s means to detoxify ammonia.

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The results of ammonia resemble these of lactic acid (lactate) – it’s a metabolic waste product that creates bodily and psychological fatigue because it builds up in neural and muscular tissues.^[27,28] Bettering your physique’s means to take away ammonia is one more technique for growing athletic and psychological endurance.

Citrulline does precisely that, by growing your physique’s ranges of ornithine, the amino acid answerable for driving ammonia detox.^[29,30]

Consult with the diagram above – you’ll be able to see that arginine will get transformed into ornithine as a part of the urea cycle.^[15]

Ornithine and hormones

Ornithine has additionally been proven to lower the physique’s manufacturing of cortisol, thus bettering cortisol-to-DHEA ratio that’s typically used as one measure of total hormonal well being. This may result in enhancements in emotions of stress and fatigue, however extra importantly, it appears to enhance sleep high quality.^[30]

What concerning the malate?

Malic acid (malate) has advantages of its personal. It’s required for the Krebs cycle, which is an important a part of your physique’s mobile power manufacturing.^[31]

Citrulline malate also can enhance cardio effectivity, making extra power accessible on your robust exercises.^[32]

Velvet Bean extract (Mucuna pruriens) (seed) (std. min. 98% L-DOPA) – 750 mg

Velvet bean extract boosts manufacturing of dopamine, supplying you with a “really feel good sensation” and can assist with sleep at evening.

Mucuna pruriens, often known as velvet bean, is chock stuffed with highly effective antioxidants and a identified dopamine booster.^[33] Extracts of Mucuna are sometimes standardized for L-DOPA,^[34] which is the direct precursor to dopamine.^[35]

Dopamine is the neurotransmitter most centrally implicated in focus, motivation, and reward, making it an glorious goal for pre-workout formulation.

Apart from upregulating dopamine, L-DOPA (often known as levodopa) is a strong anti-stress compound that has been proven to considerably scale back cortisol manufacturing.^[36-38] This makes it an awesome candidate for stacking with stimulants like caffeine (additionally an ingredient in Morphogen AlphaGen), as it may possibly assist take the sting off of your stimulant buzz.

Cortisol discount is normally a great factor for gymnasium goers, since an excessive amount of cortisol can scale back testosterone ranges^[39,40] and doubtlessly intrude with muscle progress.

In relation to muscle progress, Mucuna and L-DOPA have been proven to upregulate the physique’s manufacturing of progress hormone (GH),^[41-43] which is one other anabolic hormone.

L-DOPA also can assist management prolactin ranges,^[44] which is normally a great factor for a pre-workout formulation since prolactin tends to be elevated after train.^[45]

AlphaGPC (Alpha-Glyceryl Phosphoryl Choline) – 600 mg

AlphaGPC is a type of choline, the B vitamin most vital for serving to the physique construct and preserve the phospholipid bilayer membranes that enclose the contents of all of the physique’s cells.^[46] It’s additionally required for lots of the intercellular signaling features that these membranes perform.^[47]

Choline is required for the synthesis of acetylcholine, an vital neurotransmitter that facilitates studying and reminiscence.^[48] We frequently name acetylcholine “the training neurotransmitter” due to how essential it’s for these processes.

Supplemental choline can upregulate acetylcholine, resulting in improved cognitive efficiency.^[49,50]

Lastly, choline is a vital methyl donor throughout the strategy of methionine metabolism – that is essential in mild of the truth that extra methionine buildup is linked to heart problems.^[51]

We like alphaGPC as a result of, in contrast to different types of choline, it readily crosses the blood-brain barrier^[52] and is extra bioavailable.

Advantra Z Bitter Orange Extract (Citrus aurantium) (fruit) (Std. min. 10% synephrine) – 500 mg

Bitter orange extract is standardized for an alkaloid known as synephrine, which is a good fats burning and efficiency boosting ingredient.

Morphogen Diet’s Intra Exercise Stack brings a complete of three grams of taurine and tons of different amino acids and electrolytes

Analysis has proven that taking synephrine can improve the physique’s each day caloric expenditure by as a lot as 183 energy,^[53] which is certainly nothing to sneeze at for a low-effort calorie burn. A 183 calorie deficit interprets into about 1.5 kilos of fats loss monthly.

One examine discovered that the mixture of synephrine and caffeine (a mixture now we have in Morphogen AlphaGen) elevated college-aged males’s weightlifting quantity by 10% in a single session.^[54] Synephrine alone additionally triggered a rise.

Synephrine works as a result of it’s a beta agonist,^[55] the identical mechanism of motion behind the notorious stimulant ephedrine. Don’t fear although – synephrine is far much less intense than ephedrine,^[55] with little to no impact on coronary heart fee or blood stress.^[56]

Caffeine (as Caffeine Anhydrous USP) – 400 mg

Caffeine is probably the most extensively used authorized stimulant on the planet. An amazing majority of American adults devour caffeine in some type every day, principally due to the substance’s means to keep at bay fatigue, which helps us get via jam-packed days with out lacking a step.

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One factor that makes caffeine stand out is its means to cross the blood-brain barrier. That is one thing most dietary dietary supplements can’t do, and it’s what offers caffeine such a strong means to affect the workings of the central nervous system.^[57]

Equally to its fellow methylxanthine and shut cousin theobromine, which can be current in Morphogen AlphaGen, caffeine blocks the motion of adenosine, a nucleotide that builds up within the mind throughout wakefulness, progressively worsening psychological fatigue.^[58]

Fatigue is commonly an enormous difficulty for anybody making an attempt to drop pounds, since caloric restriction can put an enormous dent in power ranges. That’s one cause why dieters typically drink liberal quantities of tea or espresso.i It’s additionally one cause why we prefer to see caffeine in fat-burning dietary supplements.

Caffeine burns fats and energy – cAMP and mobile metabolism

However caffeine may also help you burn fats extra instantly too, by upregulating mobile power manufacturing. This interprets into elevated each day calorie burn.

The mechanism of motion is inhibition of phosphodiesterase, the enzyme answerable for breaking down the hormone-like messenger molecule, cyclic adenosine monophosphate (cAMP).

Since cAMP alerts cells to burn extra glucose and fatty acids for power, elevating cAMP ranges via phosphodiesterase inhibition finally means a sooner metabolism – extra energy burned in a day.^[59-61]

Upregulating cAMP via caffeine use is especially good at dashing up the physique’s fee of fats burning. Animal research on caffeine have discovered that supplementation can improve it by as a lot as 50%.^[62]

Caffeine improves train efficiency – further calorie burn

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After all, burning extra fats at relaxation is an effective way to speed up fats loss – assuming you maintain your calorie consumption fixed, and don’t eat extra to cowl any deficit.

Most of us know that train is an effective way to burn extra energy. And, because it seems, caffeine may also help us try this too.

Because of the way it ramps up mobile metabolism, caffeine can enhance a number of dimensions of bodily efficiency, together with energy, pace, and endurance.^[63]

Cognitive and psychological advantages

Caffeine also can improve attentiveness, alertness, response occasions, and dealing reminiscence.^[64-66]

Though it might sound counterintuitive, psychological and cognitive advantages are a welcome addition to fat-burning dietary supplements. Loads of analysis truly signifies that caloric restriction does not considerably impair cognition,^[67] or, maybe, it could enhance it.^[68] However, anecdotally, lots of people report feeling low on psychological power after they scale back meals consumption. Caffeine can doubtlessly assist compensate for that.

N-Phenethyl Dimethylamine Citrate (Eria Jarensis extract) (complete plant) – 300 mg

N-phenethyl dimethylamine is a stronger model of a molecule known as phenethylamine (PEA).

If you happen to aren’t accustomed to PEA, simply know that it’s an alkaloid extensively thought-about probably the most highly effective stimulants on the nutritional-supplement market.

Eria Jarensis Extract is a pure supply of N-phenethyldimethylamine – it’s an awesome power booster and temper elevator!

Taking PEA triggers a large launch of catecholamine neurotransmitters like dopamine, adrenaline, and noradrenaline, which may enhance temper and offer you extra power.^[69]

Sounds nice, proper? Nicely, there’s one large difficulty with PEA’s usefulness as a complement: its brief half-life. As soon as in your bloodstream, PEA is damaged down very quick by an enzyme known as monoamine oxidase (MAO). even an enormous dose of PEA will solely offer you about 5 minutes of impact.^[70,71]

That is why N-phenethyl dimethylamine is now getting used as a substitute for PEA. It incorporates two alkyl teams that buffer it towards MAO, which means it has a for much longer impact than bizarre PEA.^[72]

If you wish to be taught extra about N-phenethyl dimethylamine, learn our long-form article, Eria Jarensis Extract / N-phenethyl dimethylamine: The Subsequent Massive Factor?

Please notice that 300 milligrams of N-phenethyl dimethylamine is an enormous dose. If you happen to aren’t certain the way you’ll react, ask your physician, and contemplate beginning with a partial dose of Morphogen AlphaGen.

Theobromine (from Cocoa extract) (Theobroma cacao L.) (seed) (std. min. 99%) – 200 mg

Theobromine belongs to the methylxanthine class, which additionally contains caffeine.

It has stimulant, bronchodilatory, and vasodilatory results.^[73]

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Like caffeine, theobromine is a phosphodiesterase inhibitor, which, once more, has the impact of accelerating cyclic adenosine monophosphate (cAMP) ranges^[74] and growing the speed of caloric expenditure by upregulating mitochondrial operate and growing mobile power manufacturing.^[75,76]

So what’s the distinction between caffeine and theobromine? In a nutshell, caffeine is primarily a central nervous system stimulant, whereas theobromine is far more targeted on stress-free easy muscle.^[77]

Clean muscle traces the within of blood vessels, so theobromine can truly scale back blood stress, whereas caffeine is thought for growing it.^[78]

Actually, stacking theobromine with caffeine can truly negate caffeine’s impact on blood stress,^[78] which makes this a wise ingredient mixture. With each of those methylxanthines in the identical formulation, you’re getting the upside of caffeine with much less draw back.

Theobromine also can profit cardiovascular well being by optimizing nitric oxide manufacturing and performance.^[79]

L-Theanine (HPLC) – 100 mg

L-Theanine comes from tea leaves, and pairs very properly with caffeine offset any potential nervousness.

Theanine is an amino acid that happens naturally in Camellia sinensis, the plant from which we get white, inexperienced, oolong, and black teas.

Within the human mind, theanine acts like a neurotransmitter^[80] and has stress-free, anti-anxiety results associated to its inhibitory impact on neurotransmission.^[81-83]

What makes theanine such an superior complement is that it does all of this with out inflicting sedation, offering the most effective of each worlds.

Theanine can be extremely secure and dust low-cost. This mix of efficacy, security, and inexpensiveness has made theanine a mainstay nootropic ingredient for the reason that biohacking craze of the early 2010s.

Caffeine + theanine: match made in heaven

It was again within the good outdated days when folks searching for a aggressive edge found theanine’s means to synergize with caffeine (one other ingredient in Morphogen AlphaGen).

The mixture of theanine and caffeine has optimistic results on temper and cognition that outperform the results of both ingredient alone.^[84]

In a landmark 2008 examine, researchers who examined the results of caffeine, theanine, and the mix of each found that the mixture was higher than both ingredient alone at bettering psychological accuracy, lowering emotions of fatigue, dashing up response occasions, and growing numerical working reminiscence. The mix was additionally higher at bettering the flexibility to guage written texts, and at growing alertness.^[84]

L-Theanine will increase consideration and reduces response time — particularly in harassed people!^[85]

Talking extra anecdotally and subjectively, veteran biohackers can inform you that theanine actually takes the sting off caffeine, offering a peaceful, targeted feeling with out the soiled, jittery nervousness that normally comes with caffeine use.

Theanine can be nice for bettering sleep high quality and lowering resting coronary heart fee.^[86]

One of many large mechanisms behind all of those results is theanine’s means to upregulate GABA,^[87] a chilled neurotransmitter that exerts inhibitory results on neurotransmission.

Huperzine A (from Huperzia serrata extract) (leaf and stem) (std. min. 1% Huperzine A) – 300 mcg

Identical to alphaGPC can enhance acetylcholine ranges by growing manufacturing, huperzine A can enhance acetylcholine by slowing the speed at which it’s damaged down.

It does this by inhibiting the enzyme acetylcholinesterase, which is answerable for degrading acetylcholine.^[88]

Due to their complementary results on acetylcholine ranges, we regularly see huperzine A and alphaGPC stacked collectively, as in Morphogen AlphaGen.

Nevertheless, huperzine A is definitely a strong sufficient acetylcholinesterase inhibitor that may independently have a major impact on acetylcholine ranges.^[89]

Once more, we would like extra acetylcholine, the training neurotransmitter, due to its means to facilitate inter-neuronal communication and long-term potentiation (LTP).

However huperzine A can be a strong antioxidant, and may shield neuronal mitochondria from oxidative stress harm.^[90]